Viktor Vaughn wrote on Oct 1
st, 2014 at 3:08pm:
Can you at least use mouse in 2 for mouse look?
I believe in 2 controls are much better. 1 was known to be a really bad port so I avoided it even when my console friends were raving about it.
I use mouse in 2 for mouselook and target lock. Target lock is really invaluable, but you have to learn when to acquire and when to let go of the target since your positioning and movement change dramatically between having a target locked and not having one locked. Also, because weapons have a "sweet spot" where damage is maxmized on the strike (way more complicated than DDO damage mechanics in terms of maxmizing a strike itself), not locking the target usually lowers your DPS because you can be "too close" to an enemy and lose damage on a strike. When you're locked on, you're going to stay at the proper distance to hit with the sweet spot of the weapon you're holding (assuming you're close enough to hit).
Only time I use unlocked targeting on 2 is when using binoculars (you can't do both at the same time), then you have aim usuing your best judgement (no target crosshair - unless you paste one on your monitor/overlay). It take a bit to get the hang of it, but once you do, it will become second nature. Just much more active combat than DDO and way less cushy.
There's a really good wiki for DS2 as well.
I remember the first time I hung out on a ladder thinking the mobs wouldn't chase me only to turn around and see one had climbed up and proceeded to knife me to death in the back.

ETA: Despite the active combat, it's not a platformer, so people who complain about DDO's sometimes Mario-like jumps won't find it there. It much more like a pure fighting game, where you have to bait attacks, then counter, then bait some more. You get greedy you die. You get sloppy you die.
I've beaten about 3/4 of the bosses in 2 as well on NG. Some of them I beat on the first pass through. Most it took a couple deaths to get my attack plan to work, and a few took a lot of deaths to finally beat. I've played a lot of the game in fully hollowed mode though, so -50% health, which means I can usually only survive 1 hit between healing, and sometimes not even that from some bosses.
I also love that to maximize farming drops, you pretty much have to run around in gear where you might as well be naked. Farm at your own risk.