*Update: 07/17/15
Leveling Path (50% pot, 5% shrine, 10/25% tome, 5% voice)SPIES IN THE HOUSE - 20-25 for bravery bonusEE Spies (First time elite, BB, BB streak, daily, vandal, onslaught, ingenious, shrine, voice, 50%, optionals, tome, no death, no reentry): ~271k exp
EH Spies (First time hard, vandal, onslaught, ingenious, shrine, voice, potion, tome, optionals, no death, no reentry): ~174k
EN Spies (First time normal, vandal, onslaught, ingenious, shrine, voice, potion, tome, optionals, no death, no reentry): ~159k
First ~30 minutes, get ~604 exp. Not hard to do with a group of levels 20-25 to get that EE BB.
THE JUNGLE OF KHYBER (VON3) - 20-26 for bravery bonusEE VoN3 (First time elite, BB, BB streak, daily, ransack, conquest, ingenious, shrine, voice, 50%, optionals, no deaths, no reentry): ~179k
EH VoN3 (First time hard, ransack, conquest, ingenious, shrine, voice, 50%, optionals, no deaths, no reentry): ~118k
EN VoN3 (First time nomral, ransack, conquest, ingenious, shrine, voice, 50%, optionals, no deaths, no reentry): ~109k
Takes an hour or so for all three runs, netting less than 406k xp. Run with a party of level 20-26 to obtain bravery bonus. Note, the exp is absolute max, given all the optionals spawning. This will not be the case. Exp will be less based on number of optionals spawning, trap bonus, etc.
THE CHAMBER OF RAIYUM (WIZ KING) - 20-26 for bravery bonusEE WizKing
EH WizKing
EN WizKing
AN OFFERING OF BLOOD (OOB) - 20-25 for bravery bonusEE OOB (First time elite, bb, bb streak, daily, shrine, voice, 50%, no death, no reentry): ~120k
EH OOB (First time hard, shrine, voice, 50%, no death, no reentry): ~63k
EN OOB (First time normal, shrine, voice, 50%, no death, no reentry): ~55k
OOB is a straght forward, easy quest. Just run to the end, skipping most of the optional content, and you can do this quest in 4-15 minutes a run, depending on difficulty setting. All 3 runs should take roughly 30 minutes total or less for 238k exp.
Tip for people that are wondering how to see the quest exp in game. At the end of the adventure, the little pop saying how much exp you earn is the actual exp you earned for most things (exp potion, shrine, voice, ransack, conquest, etc). It does NOT include optionals. For the optionals, you have to open the quest xp log and see how much those are individually. An example is here:

In this example, you earned 121,273 + 5,870 +
5,870 + 5,870 + 5,870 + 11,740. That is your total exp gain and it is accurate (156,493 experience). There is no hidden exp or anything of that sort. Also, worthy of note, everything but optionals DO affect the large total (121,273) whereas optionals are completely separate. What does this mean? Well, let's take Wiz King (The Chamber of Raiyum) as an example, since it is a well known quest. You can finish the quest by grabbing the scroll after killing Raiyum, without doing the other 2 towers. Then, even though the quest is "complete" you can still kill the other 2 dijiins and hafez/hami and still get all that optional experience. The stuff you can NOT earn after completing the quest are things like Ransack and Conquest.
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Example of how experience bonuses are applied, taken from ddowiki:
Misery’s Peak Elite XP = 1660
Ransack (15% of 1660) = 249
Onslaught (15% of 1660) = 249
Tome of Learning (50% of 1660) = 830
1st Elite Completion (80% of 1660) = 1328
Never played, played on elite, Bravery Bonus (20% of 1660) = 332
Elite Streak (50% of 1660) = 830
Daily playthrough bonus (20% of 1660) = 332
Flawless Victory Bonus (10% of 1660) = 166
Persistence Bonus (10% of 1660) = 166
Subtotal: 6142
Ship buff (5% of 6142) = 307
30% pot (30% of 6142) = 1842
VIP bonus (15% of 6142) = 921
Total: 9212 (by Zav on the DDO Forums)
Experience Bonuses:
First TimeFirst time on normal: 25%
First time on hard: 40%
First time on elite: 80%
DailyFirst time playing the quest that day: 20%
Bravery BonusNormal: null
Hard: 10%
Elite: 20%
Bravery Bonus StreakNormal: null
Hard: 25%
Elite: 50%
Flawless (no deaths)10%
Persistence (no reentry)10%
Killing BonusAggression: 10%
Onslaught: 15%
Conquest: 25%
Discreet: 5%
Devious: 7%
Insidious: 10%
Trap BonusTamper: 10%
Neutralization: 20%
Ingenious Debilitation: 30%
Secret Doors BonusObservance: 8%
Perception: 10%
Vigilant Sight: 15%
Breakables BonusMischief: 8%
Vandal: 10%
Ransack: 15%